Matthew was appointed Chairman on June 18, 2008 and has been a member of the Board since March 12, 2003.He is also a member of the Nomination Committee. He was the Company’s Chief Executive Officer from March 2003 to June 2008.Matthew brings to the Board his operational knowledge of Shire and his wealth of international sales, marketing, integration and operational experience in the pharmaceutical sector. Matthew is a Director of Vertex Pharmaceuticals Inc.He served as Chairman, CEO and President of Vertex Pharmaceuticals Inc. from 2009 until early 2012 and is a former Director of Incyte Corporation.